The quality of pediatric oncology clinical trials that include radiation therapy is linked to the quality of guidelines. Radiation oncology is an adult medical specialty; thus, pediatric radiation oncologists are uniquely positioned to work with adult cancer investigators in the reorganized US National Cancer Institute Clinic Trials Network. Learn more about the American Heart Association's efforts to reduce death caused by heart disease and stroke. Also learn about cardiovascular conditions, ECC and CPR, donating, heart disease information for healthcare professionals, caregivers, and educators and healthy living. Abstract. Down-regulation of CD20, a molecular target for monoclonal antibodies, is a clinical problem leading to decreased efficacy of anti-CD20-based therapeutic regimens. The e Clinical trials are research studies that involve people. The clinical trials on this list are studying CCR2/CCR5 Antagonist BMS-813160. All trials on the list are supported by NCI. NCI's basic information about clinical trials explains the types and phases of trials and how they are carried out Description: For the past 130 years, appendectomy has been the standard treatment for appendicitis. Recent studies from Europe have challenged the notion that surgery is the best option, showing that antibiotics alone can treat appendicitis without a need for appendectomy in as many as 3 out of 4 patients and without safety issues for up to one year of follow up. Draft ICH Consensus Principle Signed as a Principle Document, 2 March 2000, by the ICH Steering Committee important at present to refer to existing regional guidelines and to discuss the specific requirements with regional regulatory authorities, if required. This document should Antibodies that stimulate the immune system by targeting inhibitory T cell receptors were successfully introduced into oncological practice and are capable to overcome tumor-induced immune evasion. In particular, targeting of the inhibito