In this paper we address the problem of generating medical guideline for intensive insulin therapy of children with Type 1 Diabetes. We propose to build medical guideline in the form of sequential patterns using the repository of historical medical records. The idea of mining diabetes data using sequential patterns approach was proposed in Start IV insulin therapy when glucose is above target range. Insulin infusions should be Van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in the critically ill patients. N Engl J Med. 2001;345(19):1359-67. 11. Baldwin D. Rush university guidelines and protocols for the management of hyperglycemia in The purpose this guideline of is to inform the safe use of intravenous insulin for the control of blood sugars in critically ill patients. It guides the use of IV insulin infusions (sometimes referred to as sliding-scale insulin) in diabetic and non-diabetic patients for the purposes of maintaining moderate euglycaemia. 3. SCOPE The guideline also recommends against using IIT rather than conventional glucose control to normalize blood glucose in patients in the SICU/MICU, whether they have diabetes or not. Finally, the guideline recommends a target blood glucose level of 7.8 to 11.1 mmol/L (140 - 200 mg/dL) if insulin therapy is used in patients in the SICU/MICU. We suggest that a BG ≥ 150 mg/dL should trigger initiation of insulin therapy, titrated to keep BG < 150 mg/dL for most adult ICU patients and to maintain BG values absolutely <180 mg/dL using a protocol that achieves a low rate of hypoglycemia (BG ≤ 70 mg/dL) despite limited impact on patient mortality. [Quality of evidence: very low] on admission, patients were randomly assigned to strict normalization of blood glucose levels (80 to 110 mg per deciliter [4.4 to 6.1 mmol per liter]) with the use of insulin infusion or to conventional therapy (insulin administered when the blood glucose level exceeded 215 mg per deciliter [12 mmol per liter], with the infusion tapered when the … • These guidelines are designed to assist staff in meeting CSBS Standards for Diabetes. 1 2. GLYCAEMIC TARGETS IN TYPE 1 AND TYPE 2 DIABETES Target HbA1c for intensive insulin therapy derived from the UKPDS and DCCT study is 53 mmol/mol or below in Type 1 and Type 2 patients. In elderly patients symptom control and Primary treatment for type 2 diabetes using intensive insulin has the potential of quickly attaining and maintaining recommended A1C values of < 7% 2 or < 6.5%. 5 Sustained euglycemia over time without any oral antidiabetic medications or exogenous insulin after intensive insulin therapy is known as the "legacy effect." The American College of Physicians' 2011 clinical practice guideline for the use of intensive insulin therapy for the management of glycemic control in hospitalized patients recommends a blood glucose target of 140 mg/dL to 200 mg/dL in critically ill adult patients once insulin is started. 15 The 2016 American Diabetes Association's In T2DM patients, with regards to achieving glycemic goals, insulin is considered alone or in combination with oral agents when HbA1c is ≥ 7.5% (≥ 58 mmol/mol); and is essential for treatment in those with HbA1c ≥ 10% (≥ 86 mmol/mol), when diet, physical activity, and other antihyperglycemic agents have been optimally used (B). Having too much insulin to cover the carbohydrate (ie an excessive insulin-to-carbohydrate ratio.) A c