Renal Drug Handbook - GFR 20-50mls/min - dose as in normal renal function, 10-20mls/min give 75% of dose, <10mls/min - 50% of normal dose. Dialysis Renal Drug Handbook - CAPD, HD, HDF/High Flux - 50% dose. CAV/VVHD - 75% dose. CrCl (ml/min) >50 10-50 <10 Dose 100% 75% 50% Bortezomib Metabolised by oxidative debronation via CYP450 3A4, The Renal Drug Handbook: The Ultimate Prescribing Guide for Renal Practitioners, 4th edition Edited by C Ashely and A Dunleavy with a foreword by Professor David C Wheeler. Radcliffe Publishing, London, 2014. ISBN-13: 978 190936 894 1 Originally published in 1999 and updated every 5 years, the established Renal Drug Handbook provides pertinent information The Renal Drug Handbook. A universally-trusted resource, this fourth edition of The Renal Drug Handbook contains over 800 drug monographs comprising prescribing information for clinical and medicines information pharmacists. BUY NOW