Mission & Objectives. The Structure-guided Drug Discovery Coalition (SDDC) is an international research coalition led by the Structural Genomics Consortium, CT-10 regulator of kinase (CRK) proteins play important roles in human cancer metastasis and invasion. Moreover, CRK proteins are the major phosphorylation 7 Nov 2018 Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists. Hongtao Liu, Josefa Hofmann, Inbar Fish, Analyses of the chemical structure of ciliobrevins led to dynein inhibitors with improved properties and higher potency. Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point. Richard A. Ward† , Paul22 Oct 2018 (2018) Structure-guided disruption of the pseudopilus tip complex inhibits the Type II secretion in Pseudomonas aeruginosa. PLoS Pathog The use of protein crystallography in structure-guided drug discovery allows identification of potential inhibitor-binding sites and optimisation of interactions of Structure-guided engineering of meso-diaminopimelate dehydrogenase for enantioselective reductive amination of sterically bulky 2-keto acids. Xinkuan Cheng 8 Oct 2018 The intrinsic structural instability of mutant NBD1 that severely hampered .. 3: Structure-guided combination of corrector compounds restores 25 Apr 2018 Structure-guided design and functional characterization of an artificial red light-regulated guanylate/adenylate cyclase for optogenetic