The IDSA/SHEA guidelines recommend vancomycin 500 mg orally or via enteric feeding tube four times per day and adding intravenous metronidazole (500 mg IV three times per day) if the patient has ileus or significant abdominal distention (3). There are limited data on alternate antibiotic regimens for severely ill CDI patients.

Introduction. Vancomycin is a first-line therapy for methicillin-resistant Staphylococcus aureus (MRSA) and this drug is recommended for therapeutic drug monitoring (TDM) to minimize the risk of nephrotoxicity and to ensure successful therapeutic outcomes .To improve the quality of vancomycin TDM, several organizations have developed clinical practice guidelines (CPGs) for appropriate DISCLAIMER: These guidelines were prepared by the Department of Surgical Education, Orlando Regional Medical Center. They are intended to serve as a general statement regarding appropriate patient care practices based upon the available medical literature and clinical expertise at the time of development. -If trough levels are >35 mg/L, hold vancomycin, check a vancomycin level and SCr q12h, and restart with a new vancomycin regimen when the level is within the therapeutic range. The UCSF Adult Vancomycin Dosing Calculator (Excel file for download) can also be used to develop revised dosing regimens based on vancomycin levels obtained. Abstract. A panel of experts was convened by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA) to update the 2010 clinical practice guideline on Clostridium difficile infection (CDI) in adults.The update, which has incorporated recommendations for children (following the adult recommendations for epidemiology, diagnosis, and treatment Vancomycin Dosing (intravenous intermittent administration) and Monitoring of Drug Level Guidelines for PICU patients Dose: • Neonatal > 35 weeks gestation - 18 years: 15mg/kg iv every 6 hours (Maximum dose 3 g) Administer ov